Key Points Direct oral anticoagulant (DOAC) plasma concentrations are closely associated with the efficacy and safety of DOAC therapy and concomitant
Arch Intern Med
Abstract The direct oral anticoagulants (DOACs), dabigatran, rivaroxaban, apixaban, and edoxaban, are becoming the most commonly prescribed drugs for
View interaction reports for Pradaxa (dabigatran) and the medicines listed below
Severity: Severe
A 77-year-old man developed upper gastrointestinal bleeding while receiving amiodarone and dabigatran etexilate concurrently
5-fold (or greater than 150%) will require Dabigatran
Call your doctor for medical advice about side effects
There's not enough information to say that other herbal remedies and supplements are safe to take with dabigatran
Of 108 dabigatran-dronedarone interaction cases, 51 were associated with bleeding events
5 [ 47 ], resulting in an oral bioavailability of only 7
52, 95 Dabigatran: ↑ MB (1 retrospective cohort 15), dabigatran 75 mg bid + amiodarone 200 mg daily with rectal bleeding –↓ renal function with dabigatran trough concentration at 5600 ng/mL In all cases, to minimize potential interaction, dabigatran should be given at least 2 hours before verapamil
Arch Intern Med
Increasing age, female sex, cardiac disease, and some metabolic disturbances (notably hypokalaemia) predispose to QT prolongation
Comments
Dabigatran has moderate interactions with at least 151 different drugs
2015; 43:1661–1669
16 Dabigatran is metabolized